The Glucarate Report
Reproduced by permission / license from
AMC Cancer Research Center, Denver Colorado
Personnel titles have been changed to reflect current position.

• Article
• Interview with Dr. Thomas Slaga, AMC Cancer Research Center

D-Glucarate Helps Remove Toxins and Carcinogens From the Body

Cancers develop gradually as a result of a complex interaction of factors related to heredity, environment, lifestyle, and diet. Based on sound scientific estimates, it can be stated that greater than 80 percent of all cancer deaths are related to the use of tobacco products, to what we eat and drink, to exposure to sunlight and ionizing radiation and to exposure to cancer-causing chemicals found in the environment and the workplace. No doubt, some people are more sensitive than others to factors that cause cancer; however, personally controlled lifestyle factors account for the major cancer risk experienced by mankind.

More than 200 epidemiological studies show that a diet high in fruits and vegetables leads to a decrease in cancer as well as other degenerative diseases. In addition, thousands of human and experimental animal studies show the protective effects of vitamins, minerals, antioxidants and other beneficial phytochemicals against cancer and other degenerative diseases. D-glucarate is a nontoxic, natural substance found in both fruits and vegetables, and many studies have shown it be highly protective against cancer. The health benefits of D-Glucarate were discovered by researchers at the M.D. Anderson Cancer Center, the No. 2 cancer center in the United States. The have developed a patented form of glucarate for use in dietary supplements.

In experimental animal studies, D-glucarate has been shown to decrease lung, skin, liver, breast and colon cancers by 60 percent or more. In addition, D-glucarate has been found to have an inhibitor effect on cancers of the bladder and the prostate.

In the breast, D-glucarate has been shown in more than 20 experimental animal and in vitro studies to significantly inhibit cancer. D-glucarate inhibits the induction of breast cancer by a variety of chemical carcinogens and tumor promoters including estrogens D-glucarate has been found to work synergistically with both retinoids and tamoxifin to prevent the induction of breast cancer. The primary mechanism of action of D-glucarate is through its ability to enhance detoxification of both chemical carcinogens from the environment and estrogenic tumor promoters produced by the body. Women who are at a higher risk for breast cancer have a lower detoxification capacity for carcinogens and estrogens. Several human trials are currently underway with D-glucarate to determine its capability to decrease the breast cancer risk in women at a high risk for breast cancer.

Likewise, D-glucarate has been found to effectively prevent the induction of prostate cancer in men. An enhancement of the detoxification of carcinogens and androgens appears to be the mechanism by which D-glucarate inhibits prostate cancer. Several experimental animal studies have likewise shown the protective effect of calcium D-glucarate against colon cancer induced by various potent carcinogens. Once again, the mechanism by which calcium D-glucarate inhibits colon cancer appears to be related to the enhancement of the detoxification of both carcinogens and sterol tumor promoters.

In studies of lung cancer, a leading cause of death in this country, D-glucarate has been shown to effectively inhibit the induction of this form of cancer in experimental animal studies using different types of carcinogens found in cigarette smoke. Detoxification of the carcinogens appears to be the major mechanism of action.

D-glucarate also appears to have beneficial applications with cancers of the liver, bladder and skin; although, more research is needed. In all reviewed cases, the mechanism of action of D-glucarate appears, once again, to be related to the enhanced detoxification and inhibition of cell proliferation.

Of particular importance, the protect effect observed in experimental animal studies of D-glucarate and its derivatives against cancers of the breast, prostate, colon, lung, liver, bladder and skin appears associated with a considerable inhibition of both the initiation and promotion stages of carcinogenesis. Similar amounts of a calcium control — calcium gluconate — did not provide protection. In a review of all studies performed to date, D-glucarate and its derivatives appear promising as chemopreventive agents against several different cancers.

The mechanism by which D-glucarate enhances the detoxification of carcinogens, steroids, and sterols seems to be associated with its ability to inhibit the enzyme ß-glucuronidase. The major mechanism by which carcinogens, steroid hormones and sterols are detoxified is through a process called conjugation by glucuronidation. ß-glucuronidase effectively reverses this reaction allowing active carcinogens and tumor promoters to do further damage.

It is important to note that D-glucarate is a natural compound produced in small amounts by mammals, including humans, and by some plants. Studies of D-glucarate and its derivatives reveal no toxicity when consumed in large amounts, making it a safe substance to ingest. If glucarate were not produced in small amounts by the human body, it would be more than likely be classified as a vitamin because of its beneficial role in protecting against cancer. Dietary sources of D-glucarate include different fruits and vegetables. The highest amounts of D-glucarate are found in fruits, especially apples, grapefruits, cherries, and apricots. Significant amounts are also found in vegetables including broccoli, brussel sprouts and alfalfa sprouts.

In Brief 
Glucarate is a component of fruits and vegetables and is present in the human body.
Glucarate is safe; no toxicity has been detected.
Glucarate is a pure compound that's molecular structure and mechanism of action is well defined
Glucarate supports the major detoxification pathway in the body: glucuronidation. This is the body's primary defense against cancer-causing agents.
Shown to inhibit the development of cancers in laboratory animals in more than 30 studies published in cancer research journals.
Glucarate in lab animals has been shown to be effective in preventing breast, lung, prostate, akin, colon, bladder and liver cancers.
Clinical trials are underway by the National Cancer Institute and the AMC Cancer Research Center on glucarate as a cancer-preventative agent.
Epidemiological evidence shows a positive correlation between higher glucarate levels and reduced cancer risk.
Researchers at M.D. Anderson Cancer Center, the No. 2 cancer center in the United States, developed a patented form of glucarate used in dietary supplements.
Recommended daily supplement dosage is 200 to 400 mg.

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