Calcium D-Glucarate

Fact Sheet

The Glucarate Report

Cancers develop gradually as a result of a complex interaction of factors related to heredity, environment, lifestyle, and diet. Read this report to learn more about D-Glucarate and its effects on cancer.

Interview with Dr. Thomas Slaga, AMC Cancer Research Center

Dr. Thomas Slaga is the President/CEO and the Chair of the Center for Cancer Causation and Prevention at the AMC Cancer Research Center in Denver, Colorado. He oversees the development of research programs that focus on major cancer target sites, including the breast, colon, prostate gland and skin. Read a recently published interview with Dr. Slaga.

Glucarate Mechanism of Action

This slide presentation provides an overview of the methods by which Calcium D-Glucarate works to rid the body of toxins. Best viewed with Microsoft Internet Explorer.

Published Research Studies
Click here for a printable list of published research studies.

Diet, Nutrition and Cancer. National Academy of Sciences Press, Washington, D.C., 1982.

Modifiers of Chemical Carcinogenesis: An Approach to the Biochemical Mechanism and Cancer Prevention. Slaga, T.J., Editor and Contributor, Raven Press, NY. 1980(a).

Slaga, TJ. Food additives and contaminants as modifying factors in cancer induction. In: Nutrition and Cancer. Edited by G.R. Newell and N.M. Ellison, Raven Press, NY. 1980;279-90(b).

Doll R, Peto R. The cause of cancer. Quantitative estimates of available risks of cancer in the United States today. J Natl Canc Inst. 1981;66:1192-1308.

Wynder EL, Gori GB. Contribution of the environment to cancer incidence: An epidemiological exercise. J Natl Canc Inst. 1977;58:825-32.

IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. Tobacco habits other than smoking. International Agency Against Cancer. Lyon France. 1985;37.

IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. Tobacco smoking. International Agency Against Cancer. Lyon France. 1986;38.

Frei B, Editor. National antioxidants in human health and disease. Academic Press, 1994.

Steinmetz K, Potter JD. A review of vegetables, fruit and cancer I. Epidemiology, cancer causes and control. 1991;2:325-57.

Pryor WA. Antioxidants in the prevention of human atherosclerosis. Circulation. 1992;85:2337-44.

Slaga TJ, Bracken WM. The effects of antioxidants on skin tumor initiation and aryl hydrocarbon hydroxylase. Cancer Research. 1977;37:1631-5.

Slaga TJ. Inhibition of skin tumor initiation, promotion, and progression by antioxidants and related compounds. Crit Rev in Food Sci and Nutr. 1995;5(1&2): 51-7.

Walaszek Z. Potential use of D-glucaric acid derivatives in cancer prevention. Cancer Let. 1990;54:1-8.

Walaszek Z, Slaga TJ, Hanausek M, et al. Proc. Am. Assoc. Cancer Res. 1990;31:124.

Wattenberg L, Lipkin M, Boone CW and Kelloff GJ., Editors. Cancer Prevention. CRC Press, 1992.

Slaga TJ, DiGiovanni J. Inhibition of chemical carcinogenesis. In: Chemical Carcinogens, Volume 2. American Chemical Society Monograph #182. Editor C.E. Searle, American Chemical Society, Washington, DC. 1984;1279-1321.

NIH Publication No. 90-1566, What you need to know about cancer, 1988.

Slaga TJ, DiGiovanni J, Winberg LD, Budunova IV. Skin Carcinogenesis: Characteristics, Mechanisms, and Prevention. In: "Progress in Clinical and Biological Research Series - Growth Factors and Tumor Promotion: Implications for Risk Assessment," Eds. McClain M, Slaga TJ, LeBoeuf R, and Pitot H, Wiley-Liss, NY. 1995:1-20.

Sandstad O. Urinary D-glucaric acid, a marker substance for microsomal enzyme induction. Methodological aspects, responses to alcohol and findings in workers exposed to toluene. Scand J Clin Lab Invest (England). 1993;53(4):327-33.

Wattenberg, LW. Inhibition of carcinogenesis by minor dietary constituents. Cancer Research. 1992;52:2085-91.

Huang MT, Osawa T, Ho C and Rosen RT., Editors. American Chemical Society Symposium Series 546. Food phytochemicals for cancer prevention I: fruits and vegetables. American Chemical Society, Washington, DC, 1994.

Dutton GJ. Glucuronidation of drugs and other compounds. CRC Press, Boca Raton, FL, 1980.

Ames BN, et al. Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. SCI USA. 1993;90:7915-22.

Boyland E, et al. Enzyme activity in relation to cancer. Chester Beatty Research Institute: Royal Cancer Hospital, London. 1957;578-89.

Goldbarg JA, Pineda EP, Bank BM, Ruthenburg AM. A method for the colorimetric determination of B-glucuronidase in serum, urine and tissue, assay of enzymatic activity in health and disease. Gastroenterology. 1959;36:193.

Simon L, Figus Al. Diagnostic value of determination of lactate dehydrogenase and B-glucuronidase activity in gastric juice. Digestion. 1972;7:174.

Gonick HC, Schapiro A. Urinary enzymes in renal disease. Clin Res. 1967;15:358.

Reddy BS, et al. Fecal bacterial B-glucuronidase: control by diet. Science. 1974;183:416-17.

Vierbuchen M, et al. Die Bedeutung hydrolytischer enzymaktivitaeten im mammakarzinom. Verh Dtsch Ges Path. 1985;69:131-

Brochu M, et al. Comparative study of plasma steroid and steroid glucuronide levels in normal men and in men with benign prostatic hyperplasia. Prostate. 1987;11:33-40.

Kyle E, Carper A and Bowan P. Caffeine consumption and vegetarian diets affect d-glucarate acid excretion in man. Nutrition Research. 1987;7:461-70.

Walaszek Z, Szemraj J, Narog M, Adams A.K, Kilgore J, Sherman U, Hanausek M, et al. Metabolism, uptake, and excretion of a D-glucaric acid salt and its potential use in cancer prevention. Canc Detect Prevent. 1997;21(2):178-90.

Walaszek Z, et al. Reduction in vivo of the inappropriate levels of endogenous and environmental-derived compounds by sustained-release inhibitors of B-glucuronidase. United States Patent #4,845,123. July 4, 1989.

Walaszek Z, Hanausek M, Sherman U, Adams AK. Antiproliferative effect of dietary glucarate on the Sprague-Dawley rat mammary gland. Cancer Letters (Netherlands). 1990;49(1):51-7.

Dwivedi C, Heck WJ, Downie, AA, et al. Effect of calcium glucarate on beta-glucuronidase activity and glucarate content of certain vegetables and fruits. Biochem Med Metab Bi